Killed Anti-tuberculosis Vaccine and Hyaluronidase (Diffusing Vaccine)

Killed anti-tuberculosis vaccine and hyaluronidase (diffusing vaccine).

Hyaluronidase was first used in human antituberculosis vaccination in 1950 (Salhioli, 1933). From the very first it was possible to see that the addition of hyaluronidase increases remarkably the vaccinating activity of killed tubercle bacilli injected intradermally. Also it was confirmed that their diffusion offered an interesting field of study not only of vaccinating antigens consisting of m...

BCG vaccine and pulmonary tuberculosis

Tuberculosis (TB) is one of the most important public health problems in the world and has been declared as a global emergency by the World Health Organization (WHO) in 1993. Bacillus Calmette-Guérin (BCG) is one of the first developed vaccines to prevent TB. Unfortunately, BCG vaccine has had a limited duration of protection and has shown controversial and variable levels of efficacy, especial...

Vaccine Preparation and Quality Control of Killed Leishmania major

African Horse-Sickness Live and Killed Virus Tissue Culture Vaccine

Formalin-Killed Plasmodium berghei Blood Parasite Vaccine

Random-bred mice were immunized with a nonliving antigen prepared from mixed-blood forms of Plasmodium berghei, strain NYU-2, in combination with Corynebacterium parvum and/or living BCG. A high proportion of intravenously immunized mice survived virulent challenge, but subcutaneous vaccination was less effective. Vaccinated mice developed a patent infection after challenge similar to that obse...